Diabetes Insipidus may also link AIDS and CFIDS

In a recent Co-Cure posting on CFIDS, Rich Van
Konynenburg writes "we know that many PWCs have mild
diabetes insipidus."

The following appeared on the Aegis site which is
devoted to AIDS research:

Int Conf AIDS 1994 Aug 7-12; 10:196 (abstract no.
PB0797)
Harris P, Curry R; AIDS Clinical Research Center of
Washington, DC 20009.

OBJECTIVE: Ten of 200 patients have complained over
the last year of polyuria, polydipsia and nocturia. We
were interested in whether diabetes insipidus (DI) may
be directly associated with this infection.

METHODS: We measured urine and serum osmolalities,
serum antidiuretic hormone (ADH), serum sodium, BUN,
glucose and potassium levels; calculated serum
osmolalities; evaluated CD4 and CD8 counts, Beta-2
microglobulin and HIV P-24 antigen levels; assessed
recent brain scans; reviewed clinical pictures and
noted current medications.

RESULTS: ADH levels were less than 1 pg/ml, serum
osmolalities 295-312 mos/kg H2O, CD4 levels 3-564/cmm,
CD8 levels 86-1186/cmm, Beta-2 microglobulin levels
3.5-5.6 mg/l. Five had reactive HIV P-24 antigens.
Seven had essentially normal MRI's (3 not done).
Medication and secondary infection did not account for
DI.

DISCUSSION AND CONCLUSIONS: That 5% of our patients
have primary central diabetes insipidus suggests DI
may be an underestimated complication of HIV
infection.